Home » Blog » Cocaine Withdrawal: Symptoms and Medications

Cocaine Withdrawal: Symptoms and Medications

Cocaine withdrawal refers to the physical and psychological symptoms experienced by individuals trying to cease or reduce their cocaine use after a period of heavy or prolonged use.

The process can be challenging and uncomfortable due to the chemical imbalances caused by the drug’s sudden absence in the body. Understanding these symptoms and medications used to help manage cocaine withdrawal is crucial for individuals ready to take the first steps to recovery.

Cocaine Abuse and Withdrawal Overview

Cocaine abuse is a serious problem that affects countless individuals worldwide. The initial euphoria and energy boost associated with cocaine use can quickly lead to dependency, making it difficult for users to stop using the drug. However, when someone decides to quit or reduce their cocaine intake, they may experience withdrawal symptoms.

Withdrawal occurs when the body and brain adjust to functioning without the drug’s presence. Symptoms can vary in intensity and duration but often include fatigue, depression, heightened anxiety, cravings, irritability, insomnia, and even suicidal thoughts. These symptoms can make it incredibly challenging for individuals attempting to overcome their addiction.

How Cocaine Impacts the Brain

Cocaine is a powerful stimulant that significantly affects the brain’s chemistry and functioning. When it enters the bloodstream, it quickly reaches the brain and interferes with the normal communication between neurons.

One of cocaine’s primary actions in the brain is increasing levels of dopamine, a neurotransmitter associated with pleasure and reward. Dopamine buildup leads to intense feelings of euphoria, increased energy, confidence, and heightened focus. However, as repeated drug use occurs over time, the brain adapts by reducing its natural dopamine production.

Additionally, cocaine blocks the reuptake of dopamine in synapses–areas where neurons communicate–which prolongs its effect on the brain. This amplifies positive emotions and disrupts other critical functions, such as decision-making and impulse control.

Long-term or excessive cocaine use can eventually damage key regions in the brain involved in emotion regulation and memory processing. Consequently, cognitive impairments may arise along with mood disorders like depression or anxiety.

Medications Used in Cocaine Withdrawal

Currently, there are no specific medications approved by the FDA for the treatment of cocaine withdrawal. However, certain drugs may be prescribed to alleviate some of the symptoms associated with cocaine withdrawal and assist individuals in their recovery process.


Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine or sertraline may help manage depressive symptoms that often accompany cocaine withdrawal. These medications increase serotonin levels in the brain, promoting mood stabilization.


Medications like diazepam or lorazepam may be used on a short-term basis to address anxiety, agitation, and insomnia.

N-acetylcysteine (NAC)

As an antioxidant and glutamate modulator, NAC has shown promise in reducing cravings and preventing relapse during cocaine withdrawal. This over-the-counter supplement restores the glutamate balance disrupted by chronic drug use.

Other Supportive Medications

Depending on individual needs, other medications that have shown promise in managing cocaine withdrawal symptoms and relapse include propranolol, baclofen, tiagabine, topiramate, disulfiram, and modafinil. Healthcare providers might also prescribe these medications for managing specific symptoms.

Cocaine Withdrawal

Cocaine withdrawal can result in a range of physical and mental symptoms as the body adjusts to the absence of the drug. These symptoms can vary in intensity, duration, and individual experience:

Physical Symptoms

  • Fatigue and lack of energy
  • Increased appetite
  • Disturbed sleep patterns or insomnia
  • Tremors or muscle aches
  • Slowed movements or psychomotor retardation
  • Chills, excessive sweating, or flu-like symptoms

Mental Symptoms

  • Intense cravings for cocaine
  • Loss of interest in previously enjoyed activities 
  • Increased anxiety, restlessness, irritability, or agitation.
  • Depression accompanied by sadness, persistent feelings of hopelessness, and suicidal thoughts
  • Difficulty concentrating, focusing, or memory problems
  • Paranoia and hallucinations are rare but may occur

The Cocaine Withdrawal Process

Cocaine withdrawal usually begins shortly after stopping drug use. Initially, the crash phase causes individuals to experience fatigue, mood swings, and cravings. After several days into withdrawal, the acute phase can last several weeks.

Symptoms include those experienced initially, along with depression, sleep disturbances, and continued cravings. Once the symptoms peak, they gradually decline and subside. However, psychological symptoms may persist for several months or longer.

Benefits of Hand-On Care

There are several benefits to seeking hands-on care for cocaine addiction, including medical monitoring, emotional support, education, skills development, and relapse prevention. Under supervised care, medical professionals provide a safe environment for detoxification, managing withdrawal symptoms effectively, and reducing discomfort.

Symptoms of Cocaine Addiction

Symptoms of cocaine addiction can vary from person to person, but there are common signs and behaviors associated with this substance use disorder, such as: 

  • Intense cravings
  • Inability to regulate drug use 
  • Increased tolerance
  • Experiencing withdrawal symptoms
  • Neglected responsibilities
  • Impaired judgment
  • Weight loss
  • Social isolation
  • Financial problems

Cocaine Overdose Signs and Statistics

Drug overdose is a serious medical emergency that can have life-threatening consequences. Some signs and symptoms of a cocaine overdose include:

  • Agitation
  • Restlessness
  • Excessive sweating
  • Rapid heartbeat
  • Irregular heart rhythm
  • High blood pressure
  • Chest pain or tightness
  • Difficulty breathing
  • Shortness of breath
  • Dilated pupils 
  • Tremors
  • Seizures 
  • Confusion
  • Disorientation 
  • Nausea
  • Vomiting 

In severe cases, a cocaine overdose can lead to cardiac arrest, stroke, coma, and even death. According to the Centers for Disease Control and Prevention (CDC), in 2021, there were over 24,000 cocaine overdose deaths. The National Institute on Drug Abuse reported that between 25% to 40% of all fatal drug overdoses involve cocaine.

Additionally, cocaine overdose deaths have been increasing as a result of adulterated substances and combining cocaine with opioids like fentanyl. Lastly, cocaine-related overdoses are more common among males aged 35 to 44.

Cocaine Detox

Detoxification is an essential first step towards recovery from cocaine addiction, as it helps individuals safely rid their bodies of the drug. During a cocaine detox, individuals may experience various physical and psychological withdrawal symptoms.

Cocaine detox should take place under proper medical care provided in a supportive environment, enabling patients to access trained professionals who can provide vital support throughout this challenging process.

Top-Notch Cocaine Detox and Addiction Treatment in Nashville, TN

Take the first step towards reclaiming your life from cocaine addiction. Experience compassionate and effective care at Detox Nashville, a leading detox and addiction treatment center in Nashville, Tennessee. Our dedicated team provides personalized cocaine detox programs tailored to your unique needs. Don’t let cocaine control your life any longer.

Contact us now to begin your journey free from addiction.

24/7 Help Is Standing By, Call Us Now.

24/7 Help Is Standing By, Call Us Now.